Research on Biomedical Engineering
http://www.rbejournal.periodikos.com.br/article/doi/10.1590/2446-4740.0653
Research on Biomedical Engineering
Original Article

In vitro evaluation of a closed-loop feedback system for dopamine concentration control

Araujo, Carlos Eduardo de; Abatti, Paulo José; Cunha, Claudio; Gómez, Alexander; Dombrowski, Patrícia Andréia

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Abstract

Introduction: It is well known that Parkinson’s disease is related to a defi cit of dopamine (DA) in the region of the brain called the corpus striatum. The aim of this work is to demonstrate the possibility of in vitro closedloop control of the DA concentration levels. Methods: By applying the electrochemical technique of fast scan cyclic voltammetry (FSCV),ones, the measured values were compared with previously selected and the system made decisions to control infusion pumps by dynamically adjusting the DA concentration in a continuous fl ow injection cell. Low-cost hardware was used for the acquisition and control signals (Arduino board), whereas for data, processing the collected graphical programming software (LabView) was used. Results: The resolution of the system was approximately 0.4 μmol/L, with a time correction of the concentration adjustable between 1 and 90 seconds. The system allowed control of the DA concentration between 1 and 10 μmol/L with an error of approximately +/– 0.8 μmol/L. Conclusion:concentration, Although designed to control the DA the control, system could be used toFSCV, within the range of the developed the concentration of other substances or to turn on brain stimulators. These results encourage the possibility of using the system in clinical studies (in vivo)

Keywords

FSCV, Neurotransmitters, Closed-loop, Dopamine.

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