MELANINS AND PARKINSON'S DlSEASE
MELANINS AND PARKINSON'S DlSEASE
Galvão, D.S.; Caldas, M.J.
Cad. Eng. Bioméd., vol.07, n1, p.248-253, 1990
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Resumo
We have studied, using the Htckel n-eleetron approximation, a farnily of polymers descending from 5, 6, indolequinone, the most abundant monomers in melanins. Based on the presence of edge states that produces the appearance of deep midgap states aeting as deaetivator for free radicaIs, potentially citotoxic, we have built a model which is able to explain the presence of melanins in non-illuminated areas of the brain. Its relationship to the Parkinson's disease is discussed here, as well as a possible new class of chemicals to treat diseases involving hypomelanosis.
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Abstract
We have studied, using the Htckel n-eleetron approximation, a farnily of polymers descending from 5, 6, indolequinone, the most abundant monomers in melanins. Based on the presence of edge states that produces the appearance of deep midgap states aeting as deaetivator for free radicaIs, potentially citotoxic, we have built a model which is able to explain the presence of melanins in non-illuminated areas of the brain. Its relationship to the Parkinson's disease is discussed here, as well as a possible new class of chemicals to treat diseases involving hypomelanosis.
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